Detail for ALDH+/CD44+/CD24- breast CS


Full Name

ALDHhi/CD44hi/CD24-/low breast CSC

Uniprot ID

Gene Name

Not Detected

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

The tumorigenic potential of CD44high/CD24-/low CSCs could be further increased by introducing an additional (fluorescence-activated cell sorting-based) viable cell sorting step, the selection of cells based on high activity of aldehyde dehydrogenase (ALDH).

Related Pathway/CSCs feature

  • EMT

Reference

  • [1] The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation.
    Buijs, J. T., et al. (2012). Oncogene 31(17): 2164-2174. [ 21996751 ]

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