Drug name: BMP2/7 dimer


Related CSCTT Targets

TGFβ isoforms [ref.1]
ALDHhi/CD44hi/CD24/low breast CSC [ref.1]

BMP2/7 dimer

Cas.no PubChem ID
Not Detected Not Detected
Known Target
TGFβ isoforms
Introduction
Bone morphogenetic proteins (BMPs) are members of the TGFb super-family and typically appear as dimeric disulfide-linked growth factors that may regulate epithelial plasticity in normal and cancer cells. BMP homodimers (BMP2 and BMP7), and a recently described BMP2/7 heterodimer, can affect the size of the ALDHhi/CD44hi/CD24-/low breast CSC subpopulation in vitro and affect bone metastasis formation in vivo.

BMP2/7 dimer-Structure

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Reference

  • [1] The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation.
    Buijs, J. T., et al. (2012). Oncogene 31(17): 2164-2174. [ 21996751 ]

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