Drug name: Noggin


Related CSCTT Targets

BMP2 [ref.1]

Noggin

Cas.no PubChem ID
Not Detected Not Detected
Known Target
BMP2P12643
BMP4P12644
Introduction
Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6

Noggin-Structure

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Reference

  • [1] Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production.
    McLean, K., et al. (2011). J Clin Invest 121(8): 3206-3219. [ 21737876 ]

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