Drug name: Tumour-infiltrating lymphocytes


Related CSCTT Targets

CD44+/CD24- BCSC [ref.1]

Introduction

Tumor-infiltrating lymphocytes (TILs) are white blood cells that have left the bloodstream and migrated into a tumor. They are mononuclear immune cells, a mix of different types of cells (i.e., T cells, B cells, NK cells, macrophages) in variable proportions, T cells being the most abundant cells. TILs can often be found in the stroma and within the tumour itself, and are implicated in killing tumor cells. The presence of lymphocytes in tumors is often associated with better clinical outcomes.

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Reference

  • [1] Tumour-infiltrating CD8+ lymphocytes as an independent predictive factor for pathological complete response to primary systemic therapy in breast cancer.
    Seo, A. N., et al. (2013). Br J Cancer 109(10): 2705-2713. [ 24129232 ]

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