Detail for microRNA 7 family


Full Name

microRNA 7-1, microRNA 7-2, microRNA 7-3

Gene Name

MIR7-1, MIR7-2, MIR7-3

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

This miRNA has been predicted or experimentally confirmed in a wide range of species. miRNAs are transcribed as ~70 nucleotide precursors (modelled here) and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference.

Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. miRNAs are numbered based on the sequence of the mature RNA.

Multiple roles and targets of miR-7 as well as its expression pattern were linked to regulatory mechanisms and pathogenesis in glioblastoma, breast cancer and other types of cancers.

Related Pathway/CSCs feature

Reference

  • [1] MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.
    Zhang, H., et al. (2014). Stem Cells 32(11): 2858-2868. [ 25070049 ]

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