Drug name: PU-PEI


Related CSCTT Targets

CD133+ Glioblastoma cells [ref.1]

Introduction

Polyurethane-short branch polyethylenimine (PU-PEI) as a therapeutic-delivery vehicle, PU-PEI-mediated miR145 delivery to GBM-CD133+ significantly inhibited their tumorigenic and CSC-like abilities and facilitated their differentiation into CD133-non-CSCs.

polyurethane-short branch polyethylenimineSchema

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Reference

  • [1] Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.
    Yang, Y. P., et al. (2012). Biomaterials 33(5): 1462-1476. [ 22098779 ]

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