Drug name: Lentivirus vector


Related CSCTT Targets

microRNA 7 family [ref.1]
microRNA 150 [ref.2]
microRNA 145 [ref.3]
microRNA 200b [ref.4]
mircoRNA 200c [ref.4,5]

Introduction

Lentivirus (lente-, Latin for "slow") is a genus of viruses of the Retroviridae family, characterized by a long incubation period. Lentiviruses can deliver a significant amount of viral RNA into the DNA of the host cell and have the unique ability among retroviruses of being able to infect non-dividing cells, so they are one of the most efficient methods of a gene delivery vector. HIV, SIV, FIV, EIAV, and Visna are all examples of lentiviruses. Lentivirus is primarily a research tool used to introduce a gene product into in vitro systems or animal models.

Lentivirus vectors are used to carry gene fragment such like shRNA, miRNA, for different targets.

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Reference

  • [1] MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.
    Zhang, H., et al. (2014). Stem Cells 32(11): 2858-2868. [ 25070049 ]
  • [2] microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb.
    Zhang, J., et al. (2012). Int J Oncol 40(3): 747-756. [ 22025269 ]
  • [3] MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.
    Lee, H. K., et al. (2013). PLoS One 8(2): e54652. [ 23390502 ]
  • [4] Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.
    Gibbons, D. L., et al. (2009). Genes Dev 23(18): 2140-2151. [ 19759262 ]
  • [5] Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.
    Shimono, Y., et al. (2009). Cell 138(3): 592-603. [ 19665978 ]

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