Detail for ABC transporter proteins


Full Name

ABC transporter proteins

Gene Name

Related Disease

  • Ewing’s Sarcoma [ref.1]
  • Ovarian Cancer [ref.2]

Therapy Method

Function

ATP-binding cassette transporters (ABC transporters) are members of a protein superfamily that is one of the largest and oldest families with representatives in all extant phyla from prokaryotes to humans. ABC transporters are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to carry out certain biological processes including translocation of various substrates across membranes and non-transport-related processes such as translation of RNA and DNA repair. They transport a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs. ABC transporters are classified as proteins based on the sequence and organization of their ATP-binding cassette (ABC) domain(s). ABC transporters are involved in tumor resistance, cystic fibrosis and a range of other inherited human diseases along with both prokaryotic and eukaryotic (including human) development of resistance to multiple drugs.

Related Pathway/CSCs feature

  • Drug-resistance

Reference

  • [1] High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.
    Awad, O., et al.2010). PLoS One 5(11): e13943.. [ 21085683 ]
  • [2] Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population.
    Eyre, R., et al. (2014). Tumour Biol 35(10): 9879-9892. [ 24993095 ]

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