Detail for Oct4


Full Name

POU domain, class 5, transcription factor 1

Uniprot ID

Gene Name

POU5F1

NCBI ID

Related Disease

  • Pancreatic Cancer [ref.1]
  • Lewis Lung Carcinoma [ref.2]
  • Breast Cancer [ref.2]

Therapy Method

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Reference

  • [1] Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment.
    Bao, B., et al. (2012). PLoS One 7(12): e50165.. [ 23272057 ]
  • [2] Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis.
    Hu, T., et al. (2008). Cancer Res 68(16): 6533-6540. [ 18701476 ]

Back to top