Detail for VEGF


Full Name

Vascular endothelial growth factor A

Uniprot ID

Gene Name

VEGFA

NCBI ID

Related Disease

  • Pancreatic Cancer [ref.1]
  • Rectal Cancer [ref.2]

Therapy Method

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.

Related Pathway/CSCs feature

Reference

  • [1] Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment.
    Bao, B., et al. (2012). PLoS One 7(12): e50165.. [ 23272057 ]
  • [2] [1] Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
    Duda, D. G., et al. (2006). J Clin Oncol 24(9): 1449-1453. [ 16549839 ]

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