Detail for Sonic/Indian hedgehog protein


Full Name

Sonic hedgehog protein, Indian hedgehog protein

Uniprot ID

Gene Name

SHH, IHH

NCBI ID

Related Disease

  • Gastric Cancer [ref.1]
  • Acute Myeloid Leukemia [ref.2]

Therapy Method

Function

Abnormal activation of the Sonic hedgehog (SHH) pathway has been described in a wide variety of human cancers and in cancer stem cells, such as glioblastoma stem cells, CD34+ leukemic cells and breast CSCs. 

Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, mammary gland, prostate and skin. Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with hedgehog signaling. Loss-of-function mutations in Patched and activating mutations in Smoothened have been identified in patients with this disease. Abnormal activation of the pathway probably leads to development of disease through transformation of adult stem cells into cancer stem cells that give rise to the tumor. Cancer researchers hope that specific inhibitors of hedgehog signaling will provide an efficient therapy for a wide range of malignancies.

Reference

  • [1] Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer.
    Song, Z., et al. (2011). PLoS One 6(3): e17687. . [ 21394208 ]
  • [2] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells.
    Kobune, M., et al. (2009). Cancer Sci 100(5): 948-955.. [ 19245435 ]

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