Detail for CD44


Full Name

CD44 antigen

Uniprot ID

Gene Name

CD44

NCBI ID

Related Disease

  • Colon Cancer [ref.1, 3]
  • Breast Cancer [ref.1, 2, 3]
  • Pancreatic Cancer [ref.1, 7]
  • Prostate Cancer [ref.1]
  • Liposarcoma [ref.1]
  • Ovarian cancer stem cells [ref.2, 3, 4, 5]
  • Gastric Cancer [ref.3]
  • Esophageal Cancer [ref.3]
  • Lung Cancer [ref.3]
  • Head and Neck Squamous Cell Carcinoma [ref.6]

Therapy Method

Function

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Reference

  • [1] Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization.
    Bostad, M., et al. (2014). Mol Pharm 11(8): 2764-2776.. [ 24960585 ]
  • [2] A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells.
    Piotrowicz, R. S., et al. (2011). Mol Cancer Ther 10(11): 2072-2082.. [ 21885863 ]
  • [3] CD44-targeting for antitumor drug delivery: a new SN-38-hyaluronan bioconjugate for locoregional treatment of peritoneal carcinomatosis.
    Serafino, A., et al. (2011). Curr Cancer Drug Targets 11(5): 572-585.. [ 21486216 ]
  • [4] Hyaluronic acid-paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts.
    De Stefano, I., et al. (2011). Cancer Chemother Pharmacol 68(1): 107-116.. [ 20848284 ]
  • [5] Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44.
    Somasunderam, A., et al. (2010). Biochemistry 49(42): 9106-9112.. [ 20843027 ]
  • [6] Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.
    Chikamatsu, K., et al. (2013). Cancer Sci 104(11): 1468-1475.. [ 23992541 ]
  • [7] Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells.
    Bao, B., et al. (2011). J Cell Biochem 112(9): 2296-2306.. [ 21503965 ]
  • [8] Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance.
    Chang, L., et al. (2013). Cell Death Dis 4: e875.. [ 24157869 ]

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